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The main IP address: 92.222.115.128,Your server France,Roubaix ISP:OVH SAS TLD:uk CountryCode:FR
The description :diagram of glycolysis pathway - the major energetic process in living cells. aerobic and anaerobic glycolysis....
This report updates in 12-Jun-2018
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Latitude: | 50.69421005249 |
Longitude: | 3.1745600700378 |
Country: | France (FR) |
City: | Roubaix |
Region: | Nord-Pas-de-Calais |
ISP: | OVH SAS |
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Date: | Tue, 12 Jun 2018 09:19:55 GMT |
Content-Type: | text/html; charset=utf-8 |
soa: | ns1.monikerdns.net. dnsadmin.moniker.com. 2015041404 10800 3600 604800 28800 |
ns: | ns1.monikerdns.net. ns2.monikerdns.net. ns3.monikerdns.net. ns4.monikerdns.net. |
ipv4: | IP:92.222.115.128 ASN:16276 OWNER:OVH, FR Country:FR |
navigation: home | copyright | contact us | custom search enzymes: 1. hexokinase 2. phosphoglucoisomerase 3. phosphofructokinase 4. aldolase 5. triose phosphate isomerase 6. glyceraldehyde-3-phosphate dehydrogenase 7. phosphoglycerate kinase 8. phosphoglycerate mutase 9. enolase 10. pyruvate kinase compounds: atp adp glucose pyruvate published: 21 nov 2011 (4:12) , an overview (a sweet splitting process) is a central pathway for the catabolism of carbohydrates in which the six-carbon sugars are split to three-carbon compounds with subsequent release of energy used to transform adp to atp. can proceed under anaerobic (without oxygen) and aerobic conditions. why the , is the most interesting pathway for studies? first of all, this pathway is almost universal across all living organisms, and therefore all proteins or enzymes which are involved in catalysis are very similar across all organisms. secondly, is one of the ancient metabolic pathways in living cells. finally, is the first pathway which was studied in detail. , an overall equation is a 10-step pathway which converts glucose to 2 pyruvate molecules. the overall step can be written as a net equation: glucose + 2x adp + 2x nad + -> 2x pyruvate + 2x atp + 2x nadh consists from two main phases. first phase, energy investment. during this step 2x atp are converted to 2x adp molecules. second phase, energy generation. during this step 4x adp are converted to 2x atp molecules and 2x nad + are converted to 2x nadh molecules. diagram of pathway : energy investment phase step 1 : glucose phosphorylation catalysed by hexokinase : α-d-glucose + atp -> α-d-glucose-6-phosphate + adp + h + δg o = -16.7 kj/mol step 2 : isomerization of glucose-6-phosphate catalysed by phosphoglucoisomerase : α-d-glucose-6-phosphate <=> d-fructose-6-phosphate δg o = +1.7 kj/mol step 3 : second phosphorylation catalysed by phosphofructokinase : d-fructose-6-phosphate + atp -> d-fructose-1,6-bisphosphate + adp + h + δg o = -18.5 kj/mol step 4 : cleavage to two triose phosphates catalysed by aldolase : d-fructose-1,6-bisphosphate <=> dihydroxyacetone phosphate + d-glyceroaldehyde-3-phosphate δg o = +28 kj/mol step 5 : isomerization of dihydroxyacetone phosphate catalysed by triose phosphate isomerase : dihydroxyacetone phosphate <=> d-glyceroaldehyde-3-phosphate δg o = +7.6 kj/mol : energy generation phase 3-bisphosphoglycerate step 6 : generation of 1,3-bisphosphoglycerate catalysed by glyceraldehyde-3-phosphate dehydrogenase : d-glyceroaldehyde-3-phosphate + nad + +p i <=> 1,3-bisphosphoglycerate + nadh + h + δg o = +6.3 kj/mol 3-phosphoglycerate step 7 : substrate-level phosphorylation, 3-phosphoglycerate catalysed by phosphoglycerate kinase : 1,3-bisphosphoglycerate + adp <=> 3-phosphoglycerate + atp δg o = -18.8 kj/mol step 8 : phosphate transfer to 2-phosphoglycerate catalysed by phosphoglycerate mutase : 3-phosphoglycerate <=> 2-phosphoglycerate δg o = +4.4 kj/mol step 9 : synthesis of phosphoenolpyruvate catalysed by enolase : 2-phosphoglycerate <=> phosphoenolpyruvate + h 2 o δg o = +1.7 kj/mol step 10 : substrate-level phosphorylation. pyruvate synthesis catalysed by pyruvate kinase : phosphoenolpyruvate + h + + adp -> pyruvate + atp δg o = -31.4 kj/mol anaerobic and aerobic is an ancient metabolic pathway which was probably developed about 3.5 billion years ago when there is no oxygen was available. that is why main step s are not require oxygen. products from then can follow anaerobic and aerobic pathways. anaerobic pathway for anaerobic pathway there are two major fermentation processes exists. lactic acid fermentation . this pathway is common for animal cells and lactic acid bacteria. in animals the anaerobic take place in many tissues. red blood cells take most of the energy from anaerobic metabolism. skeletal muscle take energy from and from respiration. the lactate produced utilise through diffusion from the tissues to bloodstream and then to aerobic tissues, such as liver and heart. in these aerobic tissues lactate can be catabolized further or can be converted back through gluconeogenesis. one step conversion of pyruvate to lactate catalysed by lactate dehydrogenase. δg o = -25.1 kj/mol alcoholic fermentation . this two-step pathway is common for yeast. pyruvate -> acetaldehyde + co 2 catalysed by pyruvate decarboxylase. this reaction requires thiamine pyrophosphate, derived from vitamin b 1 as a coenzyme. conversion of acetaldehyde to ethanol by alcohol dehydrogenase. aerobic pathway with the present of oxygen in cells pyruvate is oxidized to acetyl-coa , which then enters the citric acid cycle . the nadh molecules are reoxidized through the with electrons transferred to the o 2 molecules. the aerobic consists from two major steps: glucose + 2x adp + 2x p i + 2x nad + => 2x pyruvate + 2x atp + 2x nadh + 2 h + + 2x h 2 o nadh oxidation pathway which generaly take place in the mitochohdrion: 2x nadh + 8x h + + o 2 + 6x adp + 6x p i => 2x nad + + 8 h 2 o + 6x atp the final net equation for aerobic : glucose + 8x adp + 8x p i + 8x h + + o 2 => 2x pyruvate + 8x atp + 10x h 2 o aerobic and anaerobic . overview the metabolism of glucose trough aerobics or anaerobic pathways is a nonoxidative process. both types of release a small fraction of potential energy stored in the glucose molecules. during the first 10 steps of , only a small part of all glucose energy is released and the rest of the potential energy is released during the last steps after . for this reason aerobic degradation is much more efficient than anaerobic metabolism. that is why the aerobic mechanism is now much more spread within living organisms, but nevertheless anaerobic pathways still take place even in animals under certain physiological circumstances. news inhibit to starve tumour cells the multi-system disease called tuberous ... role in rhabdomyosarcomas a study conducted by the idibell researchers ... other news pages: 1 copyright 2007-... by .co.uk
http://glycolysis.co.uk/adp.php
http://glycolysis.co.uk/pyruvate-kinase.php
http://glycolysis.co.uk/phosphoglycerate-kinase.php
http://glycolysis.co.uk/triose-phosphate-isomerase.php
http://glycolysis.co.uk/phosphoglycerate-kinase.php
http://glycolysis.co.uk/hexokinase.php
http://glycolysis.co.uk/atp.php
http://glycolysis.co.uk/news-1.html
http://glycolysis.co.uk/phosphoglucoisomerase.php
http://glycolysis.co.uk/newslist-1.html
http://glycolysis.co.uk/phosphofructokinase.php
http://glycolysis.co.uk/phosphoglycerate-mutase.php
http://glycolysis.co.uk/phosphofructokinase.php
http://glycolysis.co.uk/aldolase.php
http://glycolysis.co.uk/glyceraldehyde-3-phosphate-dehydrogenase.php
dehydrogenase.co.uk
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ARGS glycolysis.co.uk
PORT 43
TYPE domain
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NAME glycolysis.co.uk
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NS1.MONIKERDNS.NET 198.50.155.119
NS2.MONIKERDNS.NET 167.114.35.25
NS3.MONIKERDNS.NET 192.95.55.201
NS4.MONIKERDNS.NET 192.99.185.221
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